Have you noticed that behavior first with Ranorex 3.0.3? From this version on the Ranorex IE Add-on is signed, so I suspected this to cause the problem. However, you said that you have all signature verification options turned off ... could that be another setting?
I'm fairly sure it started happening after 3.0.3 was installed, but I cannot say for certain. I'm not sure if there are any other IE settings other than the ones I mentioned that I can disable or enable to change this behaviour. I tried a few things, but nothing mattered.
Can you temporary make an Internet connection available for that machine and try to start IE with an Internet connection just one time?
It is possible, but not something that I can do right now. Might take a day or so before I can get the access.
Could you please tell us what IE version and exact OS version you have? Then we will try to reproduce that problem with a similar machine.
Using a VM virtual machine that is Windows XP SP3 with IE 8.0.6001.18702. Also have .NET 4.0.
What I've done in the meantime is set up Ranorex on another VM that has never had it. Before install, IE launches without issues and shows about:blank immediately. The VM has VS2010, so the install put Visual C++ 2010 x86 redistributable, the Visual C++ Runtime libraries (x86), then Ranorex Main Components and the IE Add-on (I don't install the studio or samples). Upon completion, I try to launch IE and it shows the same problem. Takes about 15-17 seconds (on my machine) to show about:blank. I tried it with a restart of the OS as well. Same problem.
Thanks,
Aracknid